| 뇌졸중 환자에서 관찰되는 대뇌백질변성과 이에 관련된 위험인자 |
| 박종호, 유경호 송홍기 이병철 강우열 류상효 |
| 가천의과대학교 신경과학교실, 한림대학교 의과대학 신경과학교실 |
| Risk Factors of Cerebral White Matter Change in Patients with Stroke |
| Jong-Ho Park |
| Department of Neurology, Gachon Medical School;
Department of Neurology, Hallym University College of Medicine*, Anyang, Korea |
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| Abstract |
Background:Cerebral white matter change (WMC) is usually seen in stroke patients. This study was aimed at determining whether there might be a relationship between the extent of WMC and whether to control hypertension or not and the frequency of previous stroke lesion. Stroke subtypes were also analyzed to elucidate WMC distribution.
Methods:We investigated demographic features, vascular risk factors, subtypes, and WMC in 339 ischemic stroke patients over forty years of age who had brain MRI from the Hallym Stroke Registry between January 1998 and December 2001. In hypertension, it was divided into with therapy and with no therapy. In frequency of previous stroke lesion, we subdivided the patients into three groups by number of frequency: 0, 1, and ≥2. Stroke subtypes were classified into large artery atherosclerosis (LAA), small artery occlusion (SAO), cardioembolism (CE), and stroke of undetermined etiology (SUE). WMC was quantitatively estimated by subdividing into 5 grades (0~IV).
Results:Age, female, hypertension, previous stroke lesion, and SAO correlated significantly with prevalence of WMC (p<0.001, =0.002, <0.001, <0.001 and <0.001, respectively). In hypertension, there was significant difference between normotensive and hypertensive (p=0.001). But there was no statistical difference between with therapy and with no therapy (p>0.05). In previous stroke lesion, it showed significant difference between 0 and (1 and ≥2) (p<0.001) and between 1 and ≥2 (p<0.001). In subtype, CE also correlated significantly with prevalence of WMC as well as SAO than LAA (p<0.001).
Conclusions:WMC seen in patients with stroke is related with small-vessel disease and is mainly affected by age, female, hypertension, and previous stroke lesion. Key Words: White matter change, Age, Female, Hypertension, Previous stroke |
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