J Korean Neurol Assoc > Volume 13(3); 1995 > Article
Journal of the Korean Neurological Association 1995;13(3): 565-573.
Corticobasal Degeneration의 임상증후
이상복, 이명식, 임주혁, 문준식, 박재현, 이명종
연세대학교 신경과, 울산대학교 신경과, 이화여자대학교 신경과...
Clinical Syndrome of Corticobasal Degeneration
Sang Bock Lee, M.D., Myung Sik Lee, M.D., Joo Hyuk Im, M.D., Joon Shik Moon, M.D., Jae Hyeon Park, M.D., Myung Chong Lee, M.D.
Department of Neurology, Yongdong Severance Hospital Yonsei University College of Medicine, Asan Medical Center Ulsan University , Mokdong Hospital Ewha Womans University , Sanggye Paik Hospital Inje University
Abstract
Clinical features of corticobasal degeneration (CBD) can be characterized by an asymmetric akinetic-rigid syndrome with variable combinations of other deficits (corticospinal tract signs, supranuclear gaze palsy, cerebellar ataxia, cortical sensory loss, alien limb behavior, dystonia and myoclonus). Such unique combination of clinical features of CBD have lead to the general agreement that clinical diagnosis of CBD is reliable. We describe 6 patients presenting with clinical features compatible with CBD. Three had characteristic clinical features of CBD; one showed clinical features compatible with progressive supranuclear palsy, but also had apraxia and cortical sensory disturbances; one had an early CBD. The remaining one had clinical features compatible with CBD, but brain magnetic resonance imaging study showed multiple small lesions involving periventricular white matter and basal ganglia bilaterally.


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