Alcoholic Peripheral Neuropathy

J Korean Neurol Assoc > Volume 9(3); 1991 > Article

Journal of the Korean Neurological Association 1991;9(3): 323-331.

알코올성 말초 신경염

이상건, 박성호,나덕렬,이상수,이광우,이상복,명호진,박성혜,지제근

서울대학교 신경과,병리학. 서울시립영등포병원. 동아대학교 신경과. ?충북대학교 신경과.

Alcoholic Peripheral Neuropathy

Sang Kun Lee, M.D.*, Seong Ho Park, M.D.*, Duk Lyul Na, M.D.*, Sang Soo Lee, M.D. **, Kwang Woo Lee, M.D., Sang Bok Lee, M.D., Ho Jin Myung M.D. Sung Hye Park, M.D.***, and Je Geun Chi, M.D.***

Dep. Of Neurology, Seoul National University * Dep. Of Neurology, Dong A University ** Dep. Of Neurology, Chung Buk National University *** Dep. Of Pathology, Seoul National University

Abstract

Nerve conduction studies and sural nerve biopsies were performed on 13 patients with alcoholic peripheral neuropathy. Most patients had sensory loss and tingling sensation below knees. Wernicke's encephalopathy and pellagra dermatitis were commonly associated. There was no evidence of demyelinating newcpathy in nerve conductoion studies. Myelinated fiber oounts showed loss of small and largetbers in all patients, retaining a bimodal distribution. Segmental denyelination was not found in all teased fibers. Electron microscopy confirmed axonal degeneration of myelinated andunmyelinated fibers with seconday myelin change.