Solitary Plasmacytoma associated with Peripheral Neuropathy

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 527-533.

고립성 형질세포종에 동반된 말초신경병증 1예

노숙영, 정근호,조필자,박상철,구혜수

국립의료원 신경과. 이화여자대학교 병리학.

Solitary Plasmacytoma associated with Peripheral Neuropathy

Sook Young Rho, M.D., Keun Ho Cheong, M.D., Phil Za Cho, M.D., Sang Cheol Park, M.D.

Department of Neurology, National Medical Center

Abstract

Solitary plasmacytoma, in contrast to the disseminated neoplastic proliferation of plasma cells with marked infiltration of multiple organ system in multiple myeloma, is plasma cell neoplasm of a single focus occuring either in bone or soft tissue. The association between a solitary plasmacytoma and peripheral neuropathy is rare, and it is a progressive sensorimotorneuropathy, with a raised CSF protein and mixed demyelination and axonal loss in nerve biopsy. Localized radiotherapy indeed proves to be effective of not only arresting the progress of the neuropathy but also allowing a degree of recovery. We experienced a 55-year-old male with a solitary plasmacytoma and peripheral neuropathy confirmed by the radiologic studies, immunohistochemical stain of nasopharyngeal mucosa biopsy and sural nerve biopsy, which has loss of myelinated fiber and axonal degeneration. Until now, the reported cases are very rare in Korea, so we presented a case of solitary plasmacytoma associated with peripheral neuropathy.