A Case of Podophyllin Induced Peripheral Neuropathy

J Korean Neurol Assoc > Volume 7(1); 1989 > Article

Journal of the Korean Neurological Association 1989;7(1): 89-94.

Podophyllin 국소도포후 발생한 말초신경병증 1예

이상수, 노재규,이광우,하충건,이상복,명호진,지제근

서울대학교 신경과, 병리학.

A Case of Podophyllin Induced Peripheral Neuropathy

Sang-Soo Lee,M.D., Jae-Kyu Rho,M.D., Kang-Woo Lee,M.D., Choong-Kun Ha,M.D., Sang-Bok Lee,M.D., Ho-Jin Myung,M.D., Je-G. Chi,M.D.

Department of neurology , College of medicine, Seoul National University Department of Pathology , College of medicine, Seoul National University

Abstract

Podophyllin is known as a neurotoxin, We recently observed a 34-year-old woman with podophyllin induced peripheral neuropathy. She was treated with topical podophyllin for perianal multiple condyloma acuminata. One day after application, she complained of G-I symptoms ( abdominal pain, nausea, vomiting, diarrhea), followed by tingling sensation on all extremities. We confirmed peripheral neuropathy with electrophysiologic study and sural nerve biopsy. She has improved on follow-up.