A Case of Intramedullary Myelopathy Associated with Small Cell Lung Cancer

J Korean Neurol Assoc > Volume 18(1); 2000 > Article

Journal of the Korean Neurological Association 2000;18(1): 98-101.

폐소세포암과 관련된 척수내 척수병증 1예

문희수, 김병준 ·이상무*

성균관대학교 의과대학 신경과학교실,한림대학교 의과대학 신경과학교실*

A Case of Intramedullary Myelopathy Associated with Small Cell Lung Cancer

Heui Soo Moon, M.D., B. Joon Kim, M.D., Sang-Moo Lee, M.D.*

Department of Neurology, School of Medicine, Sungkyunkwan University, Department of Neurology, Hallym University, College of Medicine*

Abstract

Subacute paraneoplastic myelopathy is a rare cause of myelopathy. Serepositivity for antineuronal nuclear antibodies-1(ANNA-1, Anti-Hu) is a sensitive and specific marker for the paraneoplastic syndrome with small cell lung cancer. A 57-year-old male patient was admitted because of acutely progressive paraparesis, anesthesia of both lower limbs and loss of bladder function over 3 days. He was subsequently found to have small cell lung carcinoma of limited stage. Magnetic resonance image of the thoracic spine showed signal abnormalities with mild focal enhancement in the intramedullary portion of C7-T10 segments. Concurrent CSF cytology showed no abnormal findings. He had high sero-logic titer of ANNA-1. These findings suggest of a paraneoplastic syndrome although we didn ’t have nectrotic patholog-ic findings. Five months after onset of neurological symptoms, he died inspite of chemotherapy and radiotherapy. We report a case of intramedullary myelopathy, probably of paraneoplastic origin, associated with small cell lung cancer. J Korean Neurol Assoc 18(1):98~101, 2000 Key Words : Paraneoplastic syndrome, Myelopathy, Antineuronal nuclear antibody-1, Small cell lung cancer