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Journal of the Korean Neurological Association 2000;18(2): 219-223.
임상적으로 진단된 Creutzfeldt-Jakob 병의 확산강조 자기공명영상 소견
이승한, 김병채이최성민이양용석이김명규이서정진*이조기현
전남대학교 의과대학 신경과학교실,진단방사선과학교실*
Diffusion-weighted Magnetic Resonance Image Findings in Clinically Diagnosed Creutzfeldt-Jakob Disease
Seung-Han Lee, M.D., Byeong-Chae Kim, M.D., Sung-Min Choi, M.D., Yong-Seok Yang, M.D., Myeong-Kyu Kim, M.D., Jeong-Jin Seo, M.D.*, Ki-Hyun Cho, M.D.
Department of Neurology, Diagnostic Radiology*, Chonnam University Medical School
Abstract
We report distinctive diffusion-weighted magnetic resonance image (DWI) findings in a 65-year-old man with clinically diagnosed Creutzfeldt-Jakob disease (CJD). Four weeks before admission he developed general weakness and febrile sense which were followed by progressive dementia, ataxia, and choreo-athetoid movement of the right hand. T2-weight-ed magnetic resonance image (MRI) showed subtle high signal intensities only in the left basal ganglia, whereas DWI demonstrated marked hyperintensities in multiple regions including the left basal ganglia and left cerebral cortex. Five weeks after the onset of symptoms, he was noted to have myoclonus and characteristic electroencephalographic changes consisting of periodic triphasic sharp waves. In our patient, high signal changes on the DWI preceded myoclonus and typi-cal EEG findings, a result suggesting that DWI may be useful in the early premortem diagnosis of CJD. J Korean Neurol Assoc 18(2):219~223, 2000 Key Words : Creutzfeldt-Jakob disease, Diffusion-weighted MRI, Basal ganglia hyperintensity