Cyclosporine-Induced Posterior Reversible Leukoencephalopathy
Syndrome With Reduced Cerebral Perfusion

J Korean Neurol Assoc > Volume 31(4); 2013 > Article

Journal of the Korean Neurological Association 2013;31(4): 270-272.

뇌관류저하를 동반한 시클로스포린 유발 가역적후뇌병증

강태호, 조기용 성상민 정대수 박규현 조한진

부산대학교 의학전문대학원 부산대학교병원 신경과

Cyclosporine-Induced Posterior Reversible Leukoencephalopathy Syndrome With Reduced Cerebral Perfusion

Tae-Ho Kang

Department of Neurology, Pusan National University Hospital, Pusan National University Graduate School of Medicine, Busan, Korea

Abstract

Posterior reversible leukoencephalopathy syndrome (PRLS) is a disorder that is characterized by reversible white-matter edema affecting the posterior regions of the brain. There are rare cases in which cyclosporine has been cited as a medication responsible for PRLS, which causes hypoperfused ischemia by endothelial injury and vasoconstriction, with resultant vasogenic edema. A PRLS patient in whom the condition was induced by cyclosporine is described herein. Perfusion computed tomography revealed a clinically relevant hypoperfused area, including the zones of vasogenic edema. Key Words: Posterior reversible leukoencephalopathy syndrome, Cyclosporine, Perfusion computed tomography