| 경동맥 스텐트삽입술 후 뇌혈관예비능의 변화: 6개월
추적 관찰연구 |
| 손승남, 정희정
a
최대섭
b,c
김록범
c
김영수
a
김수경
a,c
강희영
a
박기종
a
권오영
a
임병훈
a,c
최낙천
a,c |
| 경상대학교 의학전문대학원 신경과학교실
, 영상의학과교실
, 경남권역심뇌혈관센터 |
| Changes in Cerebral Vascular Reserve Capacity after Carotid Artery
Stenting: A 6-Month Follow-up Study |
| Seungnam Son |
| Departments of Neurology
and Radiology
, Gyeongsang National University School of Medicine, Jinju, Korea
Kyungnam Regional Cardiocerebrovascular Center
c
, Jinju, Korea |
|
|
|
|
| Abstract |
Background: Assessment of cerebral vascular reserve capacity prior to carotid artery stenting is used for predicting
hyperperfusion syndrome. However, the changes in vascular reserve capacity after carotid stenting are not fully
understood. In this study we investigated the effects of carotid artery stenting on the restoration of vascular reserve
capacity using
99m
TC-hexamethylpropylene amine oxime (HMPAO) single-photon-emission computed tomography (SPECT).
Methods: The study population comprised 29 patients who underwent carotid artery stenting. Patients were divided
into groups according to occlusion of the contralateral internal carotid artery (unilateral group vs bilateral group) and
according to the presence or absence of symptoms related to carotid stenosis (symptomatic group vs asymptomatic
group). Pre- and postacetazolamide-activated
99m
TC-HMPAO SPECT were performed prior to stent insertion and at 1
and 6?months postoperatively. Vascular reserve capacity was assessed based on pre-, and 1- and 6-month
postacetazolamide gamma count ratio (Post0, Post1, and Post6, respectively) and cerebrovascular reactivity (CVR0,
CRV1, and CRV6, respectively).
Results: The postacetazolamide gamma count ratio and cerebrovascular reactivity tended to improve at 1?month after
stenting, but tended to deteriorate at 6?months after stenting in the unilateral group compared with the bilateral group
[Post0-Post1=0.045±0.078 (mean±SD), p=0.014; Post0-Post6=0.025±0.063, p=0.042; Post1-Post6=-0.020±0.047, p=0.102;
CVR0-CVR1=0.043±0.071, p=0.008, CVR0-CVR6=0.019±0.063, p=0.097; CVR1-CVR6=-0.024±0.047, p=0.008] and in the
symptomatic group compared with the asymptomatic group (Post0-Post1=0.058±0.106, p=0.038; Post0-Post6=
0.048±0.103, p=0.061; Post1-Post6=-0.010±0.048, p=0.700; CVR0-CVR1=0.037±0.083, p=0.074; CVR0-CVR6=0.014±0.073,
p=0.344; CVR1-CVR6=-0.023±0.054, p=0.055).
Conclusions: The observed increases in postacetazolamide gamma count ratio and cerebrovascular reactivity at
1?month followed by decreases at 6?months may reflect the restoration of vascular reserve capacity. Carotid artery stenting
can improve vascular reserve capacity, especially in patients with unilateral stenosis and with symptomatic stenosis. Key Words: Carotid stenosis, Carotid artery stenting, Cerebral perfusion,
TC-HMPAO SPECT, Vascular reserve capacity |
|
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