| 알츠하이머병, 혈관성 치매 및 경도인지장애와 호모시스테인 농도 증가의 연관성 |
| 조영선, 김상범 이미선 김희진 윤지영 김건하 최경규 최병옥 |
| 이화여자대학교 의과대학 신경과학교실, 의과학연구소 |
| Association between Elevated Homocysteine Concentration and Alzheimer’s Disease, Vascular Dementia, and Mild Cognitive Impairment |
| Sun-Young Cho |
| Department of Neurology, Ewha Womans University College of Medicine, Seoul, Korea |
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| Abstract |
Background: Alzheimer’s disease (AD) and vascular dementia (VaD) are the common causes of dementia. Mild cognitive impairment (MCI) refers to the clinical condition between normal aging and dementia. Recent studies have appraised the possibility that homocysteine might play a role in the pathogeneses not only of VaD but also of AD. The purpose of this study was to investigate the relations of AD, VaD and MCI with homocysteine.
Methods: The study population consisted of 712 consecutive subjects, 629 of whom were eligible for analyses. The plasma total homocysteine was measured in 409 non-demented elderly control subjects, 102 MCI, and 118 demented patients with a clin-ical diagnosis of AD (n=68) or VaD (n=50).
Results: Homocysteine was significantly increased in patients with AD (13.9±4.1 μmol/L; p<0.001), VaD (13.6±5.8 μmol/L; p<0.01), and MCI (13.3±5.6 μmol/L; p<0.001) as compared to controls (11.3±4.6 μmol/L). Subjects in the highest homocysteine tertile had significantly higher adjusted odds ratio (AORs) for AD (AOR, 7.42; 95%CI, 3.01-18.30), VaD (AOR, 3.50; 95%CI, 1.51-8.11), and MCI (AOR, 2.40; 95%CI, 1.24-4.63). Only in the subjects with AD, the AOR was significantly higher in the middle homocysteine tertile than in the lowest tertile (AOR, 2.60; 95%CI, 1.11-6.11). In addition, homocysteine was correlated with folate, vitamin B12, age, depression, and MMSE scores, but not with schooling years.
Conclusions: In this study, significantly elevated homocysteine levels were found in patients with AD, VaD, and MCI. These findings suggest that hyperhomocysteinemia might be a risk factor for cognitive decline in the elderly.KeyWords:Homocysteine, Dementia, Alzheimer’s disease, Vascular dementia, Mild cognitive impairment |
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