The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke

J Korean Neurol Assoc > Volume 24(3); 2006 > Article

Journal of the Korean Neurological Association 2006;24(3): 210-214.

급성 뇌경색 환자에서 항혈소판제 투여 후 PAC-1과 P-selectin 발현의 변화

박선아, 김은영a 하성래 박정호 이태경 성기범 박춘식a

순천향대학교 의과대학 신경과학교실, 내과학교실a

The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke

Sun Ah Park

Departments of Neurology and Internal Medicinea, Soonchunhyang University College of Medicine, Bucheon, Korea

Abstract

Background: The purpose of this study was to evaluate the time course of PAC-1 and the P-selectin expression after the initiation of antiplatelets in acute ischemic stroke.
Methods: We serially measured PAC-1 and the P-selectin expression level using flow cytometry immediately before and at: one day, seven days, and one month after starting antiplatelets in 25 patients with acute cerebral infarctions.
Results: The P-selectin expression increased initially (p<0.05) and then from the seventh day, it began to decrease continually (post-hoc analysis, p<0.05). However, the PAC-1 expression did not reveal significant alterations during the follow-up period of one month.
Conclusions: Although the P-selectin expression rapidly declined, the PAC-1 expression remained elevated for one month. Our results suggest that the P-selectin may be useful in monitoring platelet inhibition during the early period after cerebral infarction.KeyWords:Antiplatelets, Cerebral infarction, Flowcytometry, Platelets