J Korean Neurol Assoc > Volume 21(2); 2003 > Article

Journal of the Korean Neurological Association 2003;21(2): 174-182.

베타-아밀로이드에 의한 신경세포 손상에 대한 제니스테인의 신경보호효과

방오영 , 묵인희 허 균

아주대학교 의과대학 신경과학교실,뇌질환 연구소

"Neuroprotective Effect of Genistein Against beta Amyloid-Induced Neurotoxicity"

Oh Young Bang

"Department of Neurology and Brain Disease Research Center, Ajou University, School of Medicine"

Abstract

"Background : Estrogen is beneficial to patients with Alzheimer s disease but has a limited clinical use due to its pro-liferative and oncogenic effects on non-neuronal estrogen responsive cells. Methods : In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor βagonist, with those of estrogen. Results : Genistein and 17 β-estradiol showed comparable levels of protection against A β-induced death of cultured SH-SY5Y human neurob-lastoma cells, which was blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17 β-estradiol, but not geninstein, induced proliferation of uterine endometrial cells. Conclusions : Our results suggest genistein as a potential alternative to estrogen in the treatment of Alzheimer s disease.Key Words : Estrogen, Genistein, Beta amyloid, Alzheimer s disease, Cell death, Estrogen receptor"