J Korean Neurol Assoc > Volume 19(6); 2001 > Article

Journal of the Korean Neurological Association 2001;19(6): 654-659.

노인 정상압수두증에서 단락수술과 병행하는 뇌조직 검사가 합리적인가?

정용, 진주희 권재철 서연림†박정미‡김상은‡나덕렬

성균관대학교 의과대학 삼성서울병원 신경과,진단병리과†,핵의학과‡,연세대학교 의과대학 신경과학교실*

"Is Brain Biopsy Rational in Shunt Operation of Normal Pressure Hydrocephalus in Elderly?"

Yong Jeong, M.D.*, Juhee Chin, M.A., Jay C. Kwon, M.D., Yeon-Lim Suh, M.D.†,Jung Mi Park, M.D.‡, Sang Eun Kim, M.D.‡, Duk L. Na, M.D.

"Departments of Neurology, Diagnostic pathology †and Nuclear Medicine‡,Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Neurology, Yonsei University College of Medicine*"

Abstract

Early detection of AD in its initial or preclinical stage has become increasingly important. We report a 73-year-old woman who was confirmed to have AD by a cortical biopsy performed concomitantly during a shunt operation for hydrocephalus. The triads of hydrocephalus improved after the operation, as did follow-up neuropsychological and FDG-PET findings. However, 2.5 years after the operation, the patient developed cognitive declines with abnormal behaviors, which was considered to be an evolved form of AD from the preclinical stage. Key Words : Normal pressure hydrocephalus, Alzheimer’s disease, Brain biopsy