Activated Protein C Resistance and Factor V Leiden Mutation in Patients with Arterial Ischemic Stroke

J Korean Neurol Assoc > Volume 18(4); 2000 > Article

Journal of the Korean Neurological Association 2000;18(4): 390-393.

동맥성 허혈성 뇌졸중 환자에서 활성화 C 단백 저항성과 제 5 혈액응고 인자의 돌연변이와의 연관성

변상진, 이태규 ·이준원 ·장대일 ·정경천

경희대학교 의과대학 신경과학교실

Activated Protein C Resistance and Factor V Leiden Mutation in Patients with Arterial Ischemic Stroke

Sang-Jin Byun, M.D., Te Gyu Lee, M.D., Jun-Won Lee, M.D., Dae-Il Chang, M.D., Kyung-Cheon Chung, M.D.

Department of Neurology, College of Medicine, Kyung Hee University

Abstract

Background : In the western hemisphere, resistance to activated protein C (APCR) is the most common risk factor for venous thromboembolic disease. A one-point mutation in the coagulation factor V that renders it APCR is found in more than 90% of patients with APC-resistant venous thrombosis. In Hispanic and Caucasian patients with arterial ischemic stroke, the prevalence of APC-R is approximately 10%. To determine the prevalence of APC resistance and its causative factor V mutation (Arg 506 Gln) in Koreans, we screened a group of Korean ischemic stroke patients. Methods : We evaluated 60 Korean patients with arterial ischemic stroke diagnosed by either magnetic resonance neu-roimaging, conventional angiogram, or both, after 2 weeks of symptom onset. The mean age of the subjects was 59.2 years (13-82 years). APC resistance was expressed as a ratio of the activated partial thromboplastin time (aPTT) with and without adding APC to the subject’s plasma. The presence of the factor V Leiden (Arg 506 Gln) mutation was determined by a direct polymerase chain reaction-based assay on peripheral blood leukocytes. R e s u l t s : Only one patient (n=1/60, 1.6%) had APC resistance and none were found to have the factor V Leiden (Arg 506 Gln) mutation. Conclusions : APCR and the factor V Leiden mutation do not seem to be a significant genetic risk factor for arterial ischemic stroke in Koreans. J Korean Neurol Assoc 18(4):390~393, 2000 Key Words : Activated Protein C Resistance, Factor V Leiden Mutation, Arterial Ischemic Stroke