A Case of Marchiafava-Bignami Disease with Reversible Brain MRI
Findings of Corpus Callosal Lesions

J Korean Neurol Assoc > Volume 17(5); 1999 > Article

Journal of the Korean Neurological Association 1999;17(5): 761-763.

뇌 자기공명영상상 뇌량 병변의 호전을 보인 Marchiafava-Bignami병 1예

정재훈, 성기범 안무영 신현길 박형국

순천향대학교 의과대학 신경과학교실

A Case of Marchiafava-Bignami Disease with Reversible Brain MRI Findings of Corpus Callosal Lesions

Jae-hoon Joung, M.D., Ki-Bum Sung, M.D., Moo-Young Ahn, M.D., Hyun-kil Shin, M.D., Hyung-Kook Park, M.D.

Department of Neurology, College of Medicine, Soonchunhyang University

Abstract

Marchiafava-Bignami disease(MBD), characterized by the primary degeneration of the corpus callosum, is a rare complication of chronic alcoholism. Recently, a few cases of MBD with reversible neuro-imaging abnormalities were reported. A 58-year-old, chronic alcoholic man was admitted with mental change, dysarthria, and a seizure attack. A T2-weighted Brain magnetic resonance imaging demonstrated high signal intensities in the body and splenium of the corpus callosum, multiple white matter, and cortical gray matter. Treatment with a multiple vitamin complex resulted in a near complete recovery of neurological manifestation. A brain MRI obtained four weeks after admission revealed a dramatic resolution of previous imaging abnormalities. We report a case of Marchiafava-Bignami disease with reversible neuro-imaging abnormalities. J Kor Neurol Ass 17(5):761~763, 1999 Key Words : Chronic alcoholism, Marchiafava-Bignami disease, MRI