A Clinical Study on Treatment of Myasthenia Gravis

J Korean Neurol Assoc > Volume 12(1); 1994 > Article

Journal of the Korean Neurological Association 1994;12(1): 70-79.

중증근무력증의 치료방법에 대한 임상연구

강성수, 박현미,심충섭,권오영,김승현,김주한,김명호

한양대학교 신경과.

A Clinical Study on Treatment of Myasthenia Gravis

Sung Soo Kang, M.D., Hyeon Mi Park, M.D., Choong Seop Sim, M.D., Oh Young Kwon, M.D., Seung Hyun Kim, M.D., Ju Han Kim, M.D., Myung Ho Kim, M.D.

Department of Neurology, Han Yang University

Abstract

We studied retrospectively on clinical assessment of treatment in myasthenic patients who visited on our department regularly since 1985. They were divided as a group based on therapeutic modalities such as a thymectomy, steroid therapy. Combined therapy(steroid and thymectomy), plasma exchange. And whole body irradiation. We evluated clinical effectiveness of these therapeutic modalities and come up with following conclusions. Alltherapeutic modalities showed effectiveness. In steroid therapy, thymectomy and the combined therapy. W needed at least 6-24 months for clinical improvement. In thymectomy, rognosis was depend on the number of germinal centers. In whole body irradiation. Effectiveness was shown at 5h week and continued to 6th to 12th months. We also noted that symptomatic improvement was correlated with decreased lymphocyte counts. The effect of plasma exchange was rapid but only short duration. "