A Case of Steroid Myopathy in Istrogenic Cushing Syndrome

J Korean Neurol Assoc > Volume 11(3); 1993 > Article

Journal of the Korean Neurological Association 1993;11(3): 467-470.

의인성 쿠싱 증후군에서 수반된 스테로이드 근병증 1례

심충섭, 김형철,김승현,김주한,김명호,안유헌,지제근

한양대학교 신경과, 내과. 서울대학교 병리학.

A Case of Steroid Myopathy in Istrogenic Cushing Syndrome

Choong-Sub Sim, M.D., Hyung-Chul Kim, M.D., Seung-Hyun Kim, M.D., Joo-Han Kim, M.D., Myung-Ho Kim, M.D., Yoo-Hun Ahn, M.D., Jae-Geun Jee, M.D.

Department of Neurology and Internal Medicine, College of Medicine Hanyang University, Department of Pathology, College of Medicine Seoul National University

Abstract

Steroid myopathy is one of the most common drug-induced myopathy. We report a case of iatrogenic steroid myopathy in a 61-year-old female who had taken herb medication more than 2 months. She presented a slowly progressive proximal muscle weakness and wasting with typical features of cushing syndrome. Needle EMG showed typical myopathic patterns. The muscle biopsy revealed a pronounced muscle fiber atrophy and fatty degenerative change without inflammation. In addition, there was a selective type 2 fiber depletion on ATPase staining in pH 9.4 buffer. Her muscle powers and bulks were slowly improved after discontinuation of herb medication with phenytoin and physical therapy.