Two Cases of Suspected Typhoid Encephalitis Treated with High Dose Dexamethasone

J Korean Neurol Assoc > Volume 11(2); 1993 > Article

Journal of the Korean Neurological Association 1993;11(2): 229-234.

다량의 Dexamethasone 병용치료로 치유된 장티푸스뇌염으로 의심되는 2례

강중구, 황연미,이명종,송재훈,이영상

울산대학교 신경과, 내과. 서울중앙병원 신경과, 내과.

Two Cases of Suspected Typhoid Encephalitis Treated with High Dose Dexamethasone

Joong-Koo Kang, M.D., Youn-Mee Hwang, M.D., Myung-Chong Lee, M.D., Jae-Hoon Song, M.D., Yung-Sang Lee, M.D.

Department of Neurology and Internal Medicine, College of Medicine Ulsan University Asan Medical Center

Abstract

Typhoid fever is one of the important contagious diseases. Typhoid fever of severe category is defined as the condition in which a febrile patient shows shocks or an altered state of consciousness ranging from delirium to coma. High dose dexarnethasone therapy is considered very effective in these life-threatening conditions. We report two severe hrphoid fever cases, which were treated with high dose dexarnethasone (dexamethasone 3mg/kg IV and lmg/kg q6hrs for 48 hrs) with a great success and we believe that one of the two cases is the first Korean case in the literature who had cerebellar ataxia and cortical tremor as a manifestation of the CNS involvement of typhoid fever.