A Clinical Study on Chronic Carbon Disulfide(CS2) Intoxication

J Korean Neurol Assoc > Volume 10(2); 1992 > Article

Journal of the Korean Neurological Association 1992;10(2): 136-142.

이황화탄소의 만성중독에 대한 임상적 고찰

박성호, 나덕렬,전범석

보라매병원 신경과. 뉴욕 콜롬비아대학 신경과.

A Clinical Study on Chronic Carbon Disulfide(CS2) Intoxication

Seong-Ho Park, M.D., Duk-Lyul Na, M.D., Heom-Seok Jeon, M.D.

Department of Neurology, Seoul City Boramae Hospital. Department of Neurology, College of Medicine, Columbia University

Abstract

Carbon disulfide(CS2), a volatile solvent, has been widely used in the manufacture of the artificial silk because of its highly fat-soluble property. It has been accepted that CSz is mostly absorbed to the human beings by inhalation arld does harms mainly to the central and peripheral nervous systems and the cardiovascular system. But it is conkoversial whether the pathologic changes are due to the direct toxic effects of the CS2 or to the secondary effects of the CS2-induced arteriosclerosis. Recently the authors have observed the six patients of viscose-rayon worker with a longstanding exposure to the CS2 and obtained the results as follows:1. The ages of onset in the 6 subjects (5 males and one female) were ranged from @41 to 53 years(mean;47.1) and the duration of exposure from 11 to 18 years(mean;l4.5). 2. Three of them had no hypertension. 3. Neurologically they showed headache, dizziness, general malaise, gait difficulty, visual and memory disturbances, paresthesia of distal extremities, dementia, parkinsonian features, pseudobubar palsy, spastic gait, dysarthria, hyperreflexia, and reduced or absent ankle jerks. 4. Nerve conduction studies(N=4) revealed that three of them had polyneuropathy of axonal type.