The Effect of Zonisamide in Epileptic Patients

J Korean Neurol Assoc > Volume 9(2); 1991 > Article

Journal of the Korean Neurological Association 1991;9(2): 220-227.

간질환자에서 Zonisamide의 효과에 대한 연구

이광수, 안재훈,김범생,강민수,정성우,김영인,정미라,이해선

가톨릭대학교 신경과. 한국의학연구소. 부천제일병원.

The Effect of Zonisamide in Epileptic Patients

Kwang Soo Lee, M.D., Jae Hoon Ahn, M.D., Beum Saeng Kim, M.D., Min Soo Kang, M.D., Sung Woo Chung, M.D., Yeong In Kim, M.D., Mi Ra Chung, M.D.*, Hae Seon Lee, M.D.*

Dep. Of Neurology, Catholic University Korea Medical Institute, Bucheon Jeil Hospital*

Abstract

We have studied thirty two cases of inappropriately treatable and intractable epileptics to various anti-convulsants. Zonisamide had a definite anti-epileptic activity in eleven subjects(52.4%) of intractble epilepsy. Five patients(45.5%), who were previously inappropriately treatable epileptic patients became seizure free on zonisamide. Two subjects were withdrawn from study because of side effect and two subjects were also withdrawn because of uncontrolled seizure. Zonisamide is not only effective in intractable epileptic patients but also in first trial for untreated epileptic patients.