Ferritin Level Cereberospinal Fluid in Patients with Tuberculdus Meningitis

J Korean Neurol Assoc > Volume 9(2); 1991 > Article

Journal of the Korean Neurological Association 1991;9(2): 32-38.

결핵성 뇌막염환자에서의 뇌척수액 ferritin 농도의 변화

신동진, 정경천,김명호

한양대학교 신경과

Ferritin Level Cereberospinal Fluid in Patients with Tuberculdus Meningitis

Dong Jin Shin, M.D., Kyung Cheon Chung, M.D., Myung Ho, Kim, M.D.

Dep. Of Neurology, Hanyang University

Abstract

By means of a sensitive radioirnrnunoassay method,ferritin was assessed in the cerebrospinal fluid (CSF) of 50 hospitalized subjects to evaluate its potential value for the diagnosis of tuberculous rneningititis. The rnean ferritin value obtained in the controls was 4.29ng /rnl with ranging between 1.7 and7.4ng/rmL The differences of CSF ferritin content between controls and patients with aseptic rneningitis as well as other non-infectious neurologic disorder were not significant. But rnarked elevation ranging 14 and 88ng/rnl (rnean, 37.4ng/rnl) were observed in patients with tuberculous rneningitis. And the ratio of CSF ferritin to serum ferritin in paients with tuberculous rneningitis was elevated significantly rnore than those in other groups inculuding controls, patients with aseptic rneningitis and other non- infectious neurologic disorder. The level in the serurn and CSF were independent, but that in CSF correlated vrith its total protein content. Results of this study suggest rneasuring CSF ferritin level are a valuable adjunct in differentiating aseptic meningitis from uncomplicated tuberculous meningitis.