Factors Related to Quality of Life in Patients with Parkinson's Disease

J Korean Neurol Assoc > Volume 23(6); 2005 > Article

Journal of the Korean Neurological Association 2005;23(6): 770-775.

파킨슨병 환자의 삶의 질에 영향을 미치는 요인

김성렬, 정선주 성영희 임주혁 이명종

울산대학교 의과대학 신경과학교실

Factors Related to Quality of Life in Patients with Parkinson's Disease

Sung Reul Kim

Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea

Abstract

Background: The goal of therapeutic interventions for Parkinson's Disease (PD) is to improve the symptoms and mitigate the effect on the Quality of Life (QOL) in the individual patient. The purpose of this study was to investigate QOL and related factors in PD patients in Korea.
Methods: Between January 1, 2004 and July 15, 2004, eighty-one PD patients were included. The patients were assessed using Parkinson's Disease Quality of Life (PDQL), Modified Beck Depression Inventory (BDI), and K-MMSE.
Results: Twenty-five male and 56 female patients were included in the study. The mean age was 60.7 years and the mean disease duration was 7 years. The male patients (p=0.07) and young age at onset (p=0.07) showed borderline correlation with PDQL score. Medical cost for PD showed significant correlation with PDQL score (p<0.001). The patients working in the daytime or spending the daytime with their spouse showed significantly higher PDQL score than those who did not (p=0.01). Among the disease characteristics, the disease duration, levodopa dosage, UPDRS score, ADL, Hoehn and Yahr stage, the presence of motor fluctuation and dyskinesia, showed that depression had a strong correlation with the PDQL score (p<0.001). On the stepwise regression analysis, the most important factor was presence of depression, disease duration and the UPDRS total score in order of strength.
Conclusions: The QOL in PD patients was strongly associated with depression, disease duration, and the severity of PD. We suggest that the assessment and proper management of depression as well as other PD symptoms is necessary to improve QOL of the PD patients.KeyWords:Quality of life, Parkinson's disease, Depression