Electrophysiological Changes by Exercise and Cold Provocation Test in a Patient with Hyperkalemic Periodic Paralysis

J Korean Neurol Assoc > Volume 18(5); 2000 > Article

Journal of the Korean Neurological Association 2000;18(5): 665-668.

고칼륨혈증 주기성마비 환자의 운동 및 한기유발검사에 의한 전기생리학적 변화

김규식, 주민경 오윤민 김승민 선우일남

연세대학교 의과대학 신경과학교실

Electrophysiological Changes by Exercise and Cold Provocation Test in a Patient with Hyperkalemic Periodic Paralysis

Gyu Sik Kim, M.D., Min Kyung Choo, M.D., Youn Min Oh, M.D., Seung Min Kim, M.D., Il Nam Sunwoo, M.D.

Department of Neurology, Yonsei University College of Medicine

Abstract

Hyperkalemic periodic paralysis and paramyotona congenita share common clinical manifestations, such as autosomal dominant diseases with missense mutations at a gene encoding α-subunit of skeletal muscle voltage sensitive sodium channel (SCN4A). Exercise and cold provocation tests are physiological phenomena of clinical characteristics of these diseases. The authors experienced a case with hyperkalemic periodic paralysis and performed these tests comparing them with a patient with hypokalemic periodic paralysis and a normal person. Significant decremental changes of CMAPs were found by both tests in the case with hyperkalemic periodic paralysis, compared with those in a case of hypokalemic periodic paralysis or normal control. In conclusion, we suggest that exercise and cold provocation tests may be useful for the differential diagnosis between hyperkalemic periodic paralysis and hypokalemic periodic paralysis. J Korean Neurol Assoc 18(5):665~668, 2000 Key Words : Paralysis, Hyperkalemic periodic, Electrodiagnosis