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Journal of the Korean Neurological Association 1995;13(3): 623-630.
호산구 증다증 환자의 신경계 이상발현
윤성상, 장대일, 정경천, 서진태, 구혜수
경희대학교 신경과. 임상병리과, 이화여자대학교 해부병리과학교실
Neurologic Manifestations in Patients with Hypereosinophilia
Sung Sang Yoon, M.D., Dae Il Chang, M.D., Kyung Cheon Chung, M.D., Jin Tae Suh, M.D., Hae Soo Koo, M.D.
Department of Neurology and Clinical Pathology, Kyung-Hee Univ. Hospital, Dept of anatomical pathology, E-wha Univ. Hospital
Objective. To analyze neurological manifestations in hypereosinophilic syndrome. Background. According to Chusid et al (1975), the neurologic manifestations in hypereosinophilic syndrome were paralysis, seizure, abnon-nal EEG finding, and neuropathy. According to Weaver(1988), eosinophil-induced neurotoxicities were characterized by axonal neuropathy, cerebral infarction, and dementia. Method. We analyzed 29 patients with neurologic manifestations and hypereosinophilia who visited Kyung-hee medical center during Aug. 1991-Jul. 1994. White blood cells were differentiated by the Coulter STKS S-plus machine and confirmed manually, if hypereosinophilia had been detected, by two clinical pathologists. Symptoms, signs, imaging studies, latoratory studies and biopsies were analyzed. Result. The mean age was 47.2 years and the mean eosinophil count was 2700/cu mm. Main symptoms were hemiparesis(31.0%), dysesthesia(20.7%), headache(20.7%), dysarthria(13.8%), paraparesis(10.3%), seizure(6.9%), myalgia(6.9%), confusion(6.9%), vertijo(6.9%), diplopia(6.9%), 14patientswereshowntohavecerebrovasculardisease, 5patientsmeningoencephalitis, 4patientsperipheralneuropathy, 3 patients myelopathy. Conclusion. Cerebrovascular diseases (48.3%) were most common neurologic disease in hypereosmopluc syndrome. Others were meningoencephalitis(17.2%), polyneuropathy(13.8%), myelopathy(IO.3%), eosinophilia-myalgia syndrome(6.9Yo), temporal arteritis(3.4%). Key Words : Hypereosinophilia, Neurologic manifestations