Two Cases of Neuroleptic Malignant Syndrome

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 552-555.

Neuroleptic Malignant Syndrome 2예

배지호, 이원호,이성훈,노순기,박규현,김대성

부산대학교 신경과. 국군부산통합병원 신경과.

Two Cases of Neuroleptic Malignant Syndrome

Ji Ho Bae, M.D., Won Ho Lee, M.D., Sung Hoon Lee, M.D., Soon Ki Rho, M.D., Kyu Hyun Park, M.D., Dae Sung Kim, M.D.

Department of Neurology, College of Medicine, Pusan National University, Department of Neurology, Pusan General Armed Forces Hospital

Abstract

The neuroleptic malignant syndrome (NMS), a serious and potentially fatal complication, has been reported to occur in some patients with administration od neuroleptic medications. Its major manifestations are muscular rigidity, autonomic instability, altered consciousness, and hyperthermia, often accompanied by raised creatine kinase (CK) and leukocytosis. Manifestations of NMS are attributed to dopamine receptor blockade in the striatum, increasing thermogenesis, and in the hypothalamus, impaired heat dissipation. Owing to the potential lethality of NMS, the early diagnosis is important. The authors report two survived patients with the NMS who were treated by generalized supportive care and drug therapy