A Case of Overlap Myasthenic Syndrome

J Korean Neurol Assoc > Volume 8(2); 1990 > Article

Journal of the Korean Neurological Association 1990;8(2): 393-400.

중첩 근무력 증후군(Overlap Myasthenic syndrome) 1례

김대성, 김상호, 이상익 , 박규현, 김상욱, 정대수

부산대학교 신경과. 부산춘해병원 신경과.

A Case of Overlap Myasthenic Syndrome

Dae Seung Kim, M.D., Sang Ho Kim, M.D., Sang Ik Lee, M.D., Kyu Hyun Park, M.D. Sang Wook Kim, M.D. Dae Su Jung, M.D.*

Dep. Of Neurology, Pusan National University Dep. Of Neurology, Choon Hae Hospital*

Abstract

Myasthenia gravis (MG) differs from the Lambert-Eaton syndrome (LES) clinically, electrophysiologically, and therapeutically. However. There had been a few reports documenting the coexistence of MG and LES in the same patient, which is termed as ""overlap myasthenic syndrome"". We had studied a patient who had showed all the clinical characteristics of MG including positive response to pyridostigmin. Unlike the usual response in MG, there had been an abnormal incremental responses at post-exercise and high rate stimulation with abnormal decremental responses at low-rate stimulation in repetitive nerve stimulation test, which satisfies the diagnostic criteria of both MG as LES