The Measurement of Bone Mineral Density in Parkinson's Disease.

J Korean Neurol Assoc > Volume 16(3); 1998 > Article

Journal of the Korean Neurological Association 1998;16(3): 321-325.

파킨슨병 환자에서의 골밀도 측정

김진호, 정원영, 임건한, 오형균, 이승헌, 강상진, 류종현

조선대학교 의과대학 신경과학교실

The Measurement of Bone Mineral Density in Parkinson's Disease.

Jin Ho Kim, M.D., Won Young Jung, M.D., Gun Han Lim, M.D., Hyung Gyun Oh, M.D, Seung Heon Lee, M.D., Sang Jin Kang, M.D. Jong Hyun Reu, M.D.

Department of Neurology, Chosun University Medical college

Abstract

Background : Osteoporosis, one of the most common metabolic bone disease, might be influenced by the severity of Parkinson's disease (PD). Objectives : We investigated the relationship between the Bone Mineral Density (BMD) and the severity of PD in postmenopausal and senile women. Methods : We measured BMD of lumbar spine (L1-L4) by Dual energy X-ray absorptiometry (DEXA; Hologic QDR-4500A). We compared BMD between patient group (30 patients with PD) and control (183 postmenopausal and senile health women). The patients were divided into two groups according to osteoporosis and analyzed the following potential factors influencing BMD in PD; age, duration of symptom, age of onset, Hoehn and Yahr stage (H-Y stage), UPDRS motor score, duration of treatment, body mass index (BMI), dominant symptom such as tremor or rigidity. Results : 1. BMD was significantly decreased with aging (p <0.01) in control group, but BMD tend to decreased with aging in PD (p=0.08). 2. BMD of patient group was significantly lower than that of control group (p<0.001). 3. BMD of osteoporosis group was significantly related to BMI (p<0.05) and conversely related to H-Y staging(p <0.05), UPDRS motor score (p <0.01). 4. However, BMD of osteoporosis group were not related to age, duration of symptom, age of onset, dominant symptom and duration of treatment (p>0.05). Conclusion : Osteoporosis is related to H-Y stage, UPDRS motor score and BMI as well as aging in PD. Key Words: Bone mineral density (BMD), Osteoporosis, Parkinson's disease (PD).