Predictors of Antiplatelet Treatment Failure in Noncardioembolic Stroke

J Korean Neurol Assoc > Volume 30(3); 2012 > Article

Journal of the Korean Neurological Association 2012;30(3): 170-175.

비심장성뇌경색의 항혈소판제치료 실패의 예측인자

이동현, 김태은 허덕현 a 허태훈 박선아 이태경 성기범 박정호

순천향대학교 의과대학 부천병원 신경과, 순천향대학교 의과대학 서울병원 신경과 a

Predictors of Antiplatelet Treatment Failure in Noncardioembolic Stroke

Dong Hyun Lee

Department of Neurology, Soonchunhyang Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Neurology a , Soonchunhyang Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea

Abstract

Background: The purpose of this study is to identify the differences of risk factors and stroke mechanism between early and late recurrence in patients with long-term antiplatelet therapy for stroke prevention.
Methods: We enrolled 114 consecutive patients with recurrent infarction who had been taking antiplatelet agents regularly since previous noncardioembolic cerebral infarction. Total 81 patients (49 men and 32 women) were met to the inclusion criteria through standardized evaluation. Subjects were classified into two groups depending on the time-to-recurrence after antiplatelet therapy: early antiplatelet failure (within 2 years, n=41, hereafter as “EAF”) and later antiplatelet failure (after 2 years, n=40, hereafter as “LAF”). We investigated the differences of clinical factors between two groups using univariate and multivariate analysis.
Results: Family history of stroke (29.3% in EAF vs. 10% in LAF, p=0.029) was more frequent in EAF group. Low HDL-cholesterol and High total cholesterol/HDL-cholesterol ratio were associated with the LAF group (p=0.042, 0.005 respectively). Multivariate analysis showed that family history of stroke (OR=5.283, 95%CI 1.178-23.699, p=0.030) and previous infarction classified as large artery atherosclerosis (OR=8.497, 95%CI 1.444?50.015, p=0.018) were significant predictors for EAF whereas total cholesterol/HDL-cholesterol ratio (OR=2.002, 95%CI 1.183?3.389, p=0.010) was for LAF.
Conclusions: This study suggests that family history of stroke and cerebral infarction due to large artery atherosclerosis are more responsible for the early recurrence while dyslipidemic condition is more related to the late recurrence during long-term antiplatelet therapy in patients with previous cerebral infarction. Key Words: Antiplatelet agent, Infarction, Recurrence, Treatment failure