The Change of Platelet Aggregation with Acute Ischemic Stroke

J Korean Neurol Assoc > Volume 21(1); 2003 > Article

Journal of the Korean Neurological Association 2003;21(1): 14-19.

급성 뇌경색에서 혈소판 응집도의 변화

하병립 , 천상명 이경미 박경원 김상호 김재우 정민호 임영진 차재관

동아대학교 의과대학 신경과학교실,의과학 연구소

The Change of Platelet Aggregation with Acute Ischemic Stroke

Byung-Lyp Ha

Department of Neurology, Institute of Medical Science, College of Medicine, Dong-A University

Abstract

"Background : Platelet activation has an important role in the progression of atheroclerosis and acute ischemic events. In this study, in order to know the significance of platelet functions in a large artery atherosclerotic infarction, we evalu-ated the serial changes of platelet aggregability in patients with a large artery atherosclerotic infarction. Methods : We serially (within 24 hrs, at 72 hrs, and 7 days) measured the extents of platelet aggregation to ADP and collagen in 43 patients with acute ischemic stroke (LAA-22, SVD-21) and compared them with those in patients with asymptomatic carotid stenosis (n=20) and in normal controls (n=24). Results : The extents of platelet aggregation to ADP and colla-gen were significantly increased in large artery atherosclerotic infarctions compared to small vessel disease. These dif-ferences of platelet aggregability between the two groups were maintained for seven days after an ischemic event. However, the platelet aggregability was not different between large artery atherosclerotic infarctions and asymptomatic carotid stenosis. Conclusions : This data suggests that increased platelet aggregability is important in large artery ather-osclerotic infarction and is caused by pre-existing atherosclerotic changes rather than acute ischemic events.Key Words : Atherosclerosis, Platelet, Ischemic stroke"