Steroid Responsive Recurrent Limbic Encephalitis Associated With
LGI1 Antibodies

J Korean Neurol Assoc > Volume 32(2); 2014 > Article

Journal of the Korean Neurological Association 2014;32(2): 91-94.

스테로이드 치료에 반응을 보인 재발성 LGI1 항체연관변연계뇌염

노경하, 김승주 조재욱 신진홍 이재혁

부산대학교 의학전문대학원 양산부산대학교병원 신경과

Steroid Responsive Recurrent Limbic Encephalitis Associated With LGI1 Antibodies

Kyung-Ha Noh

Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea

Abstract

Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy. Key Words: LGI1 encephalitis, Limbic encephalitis