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Journal of the Korean Neurological Association 2014;32(2): 91-94.
스테로이드 치료에 반응을 보인 재발성 LGI1 항체연관변연계뇌염
노경하, 김승주 조재욱 신진홍 이재혁
부산대학교 의학전문대학원 양산부산대학교병원 신경과
Steroid Responsive Recurrent Limbic Encephalitis Associated With LGI1 Antibodies
Kyung-Ha Noh
Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
Abstract
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy. Key Words: LGI1 encephalitis, Limbic encephalitis