Reversible Cerebellar Leukoencephalopathy Associated With Oral
Methotrexate

J Korean Neurol Assoc > Volume 32(3); 2014 > Article

Journal of the Korean Neurological Association 2014;32(3): 168-170.

메토트렉세이트 경구복용 후 발생한 가역소뇌백질뇌병증

이주연, 오응석 정성해 손은희 이애영

충남대학교 의과대학 충남대학교병원 신경과

Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate

Juyoun Lee

Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea

Abstract

Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX. Key Words: Leukoencephalopathy, Methotrexate, Cerebellum