Guillain-Barr? Syndrome With Antibody to Ganglioside GT1a

J Korean Neurol Assoc > Volume 28(4); 2010 > Article

Journal of the Korean Neurological Association 2010;28(4): 291-294.

항GT1강글리오시드항체와 연관된 길랭-바레증후군

양태일, 박영은 김종국 a 차성이 김태형 김대성

부산대학교 의과대학 신경과학교실, 동아대학교병원 신경과

Guillain-Barr? Syndrome With Antibody to Ganglioside GT1a

Tae-Il Yang

Department of Neurology, Pusan National University School of Medicine, Busan, Korea Department of Neurology a , Dong-A University Medical Center, Busan, Korea

Abstract

The presence of serum antibodies to various gangliosides, such as anti-GQ1b, is closely related to the clinical features of Guillain?Barr? syndrome. However, the phenotype associated with anti-GT1a IgG has not yet been determined, although it has been detected in some cases of the pharyngeal-cervical?brachial variant. We report herein two patients harboring anti-GT1a IgG who both presented with profound dyspnea, dysphagia, and quadriparesis. The findings of this report suggest that the anti-GT1a antibody specifies a clinical feature of oropharyngeal palsy. Key Words: Guillain?Barr? syndrome, Oropharyngeal palsy, Anti?GT1a IgG