Guillain-Barre Syndrome With anti-GM1 and GD1b Antibodies Following Acute Hepatitis A

J Korean Neurol Assoc > Volume 26(4); 2008 > Article

Journal of the Korean Neurological Association 2008;26(4): 379-382.

급성 A형 간염 후 발생한 항 GM1과 GD1b 항체양성 길랑-바레증후군

박상순, 노 영 오세호 홍윤호 박성호

서울대학교 의과대학 신경과학교실

Guillain-Barre Syndrome With anti-GM1 and GD1b Antibodies Following Acute Hepatitis A

Sang-Soon Park

Department of Neurology, Seoul National University College of Medicine, Seoul, Korea

Abstract

Guillain-Barre syndrome (GBS) rarely develops following acute viral hepatitis, and there has been no report on the association with anti-ganglioside antibodies. Herein, we report a 36-year-old man who presented with rapidly progressive areflexic quadriparesis following acute viral hepatitis A. The results of nerve conduction study were consistent with demyelinating motor polyneuropathy, and IgG anti-GM1 and anti-GD1b antibodies were positive. Immune responses towards gangliosides may also be important mediators in acute hepatitis A-associated GBS.KeyWords:Acute Hepatitis A, Guillain-Barre syndrome, anti-ganglioside antibody