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Journal of the Korean Neurological Association 2004;22(4): 281-289.
파킨슨병의 유전인자 고찰
정근화, 전범석
서울대학교 의과대학 신경과학교실
Genetic Basis of Parkinson Disease
Keun-Hwa Jung, Beom S. Jeon
Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Neuroscience Research Institute of SNUMRC, Seoul, Korea
Abstract
Parkinson disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons from the substantia nigra pars compacta leading to the impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are likely to be implicated in the biochemical pathways underlying the etiology of sporadic PD. Our review discusses the pathogenetic mechanisms of the mutated genes. Key Words: Parkinson disease, Genetics