| Home | E-Submission | Sitemap | Contact Us |  
Journal of the Korean Neurological Association 2001;19(2): 102-109.
파킨슨병에서 레보도파의 보조요법으로서 로피니롤의 치료 효과
임주혁, 하정호 조인숙 이명종
울산대학교 의과대학 서울중앙병원 신경과
Ropinirole as an Adjunct to Levodopa in the Treatment of Parkinson’s Disease
Joo-Hyuk Im, M.D., Jeong-Ho Ha, M.D., In-Sook Cho, M.D., Myoung Chong Lee, M.D.
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine
"Background : Ropinirole is a non-ergoline D2 agonist which has a highly selective affinity to D2 receptor. The aim of this study was to evaluate the efficacy and safety of ropinirole in the treatment of Parkinson’s disease (PD). Methods : Seventy-six cases with PD (Hoehn and Yahr stage II to IV) were included in this trial. Each patient was randomly allo-cated to receive either ropinirole (n=37) or bromocriptine (n=39) over a 16-week period. All subjects were not optimal-ly controlled on levodopa due to motor fluctuations. The response rate was defined as the percentage of patients who had at least 20% reduction of levodopa doses. The clinical status was also assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), Clinical Global Impression (CGI), and reduction of off durations. Results : The end-point analysis, on an intention-to-treat basis, revealed significantly higher response rate in the ropinirole group com-pared with the bromocriptine group (odds ratio 2.995, 95% C.I. (1.157, 7.751)). A statistically significant improvement in CGI was also observed in the ropinirole group (p=0.046). The mean off duration was significantly reduced in the ropinirole group (p=0.0001). Other parameters using the UPDRS motor score or off duration did not show significant differences between the two groups. The overall incidence of adverse effects was not significantly different between the two groups. The most common side effects were dizziness, dyskinesia, and nausea/vomiting. No subjects were with-drawn from the study due to side effects. Conclusion : Ropinirole is a safe and well-tolerated drug and provides superi-or overall efficacy compared with bromocriptine as an adjunct to levodopa. J Korean Neurol Assoc 19(2):102~109, 2001 Key Words : Ropinirole, Bromocriptine, Parkinson’s disease, Motor fluctuation"