A Case of Primary Leptomemngeal Melanoma

J Korean Neurol Assoc > Volume 13(1); 1995 > Article

Journal of the Korean Neurological Association 1995;13(1): 109-114.

연수막의 원발성 악성 흑색종 1예

예종수, 김형준, 김상진, 박재현, 허 경, 조효근

인제대학교 신경과

A Case of Primary Leptomemngeal Melanoma

Jong Su Ye, M.D., Hyeong Jun Kim, M.D., Sang Jin Kim, M.D., Jae Hieon Park, M.D., Kyoung Heo, M.D., Hyo Gun Cho, M.D.

Department of Neurology, College of Medicine, Inje University

Abstract

Primary leptomeningeal melanoma is a rare and aggressive tumor that originates from pial melanin-bearing cells typically along the cerebral conveidties or at the. Base of the brain. It has been hypothesi-d that malign-t transformation Of the preexisting precursor cells leads to diffuse infiltration of the meninges by tumor and the onset of neurological symptoms and signs . The typical neurological symptoms and signs include psychiatric disturbances, seizures, and symptoros and signs of raised intracranial pressure secondary to hydrocephalus. Blindness has been reported as a late feature. Radiotherapy and chemotherapy has been using, but prognosis is poor We d be our experience with 24-years-woman m which the diagnosis of primary leptomeningea1 melanoma without melanotic pigmentation of variable areas of the skm was made.