| 뇌 글림파틱 계통: 해부학, 생리학 및 임상적 함의 |
| 전민영1,2, 정석종2, 정승호1,2 |
1연세대학교 의과대학 용인세브란스병원 신경과
2연세대학교 의과대학 신경과학교실 |
| Glymphatic System of the Brain: Anatomy, Physiology, and Clinical Implications |
| Min Young Chun MD, PhD1,2, Seok Jong Chung MD, PhD2, Seong Ho Jeong MD, PhD1,2 |
1Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea |
Corresponding Author:
Seong Ho Jeong ,Tel: +82-31-5189-8146, Fax: +82-31-5189-8565, Email: shjeong@yuhs.ac
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| *These authors contributed equally to this work |
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Received: October 30, 2025 Revised: December 3, 2025 Accepted: December 3, 2025 Published online: February 1, 2026 |
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| Abstract |
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Cerebrospinal fluid (CSF) dynamics are increasingly recognized as central to brain waste clearance. Beyond the classical view of unidirectional CSF circulation, recent studies have identified the glymphatic system and meningeal lymphatic vessels as major complementary pathways. Glymphatic transport is driven by arterial pulsation, respiration, vasomotion, and strongly enhanced during slow-wave sleep. Advances in neuroimaging, including DTI-ALPS, EPVS quantification, contrast-enhanced magnetic resonance imaging (MRI), and ultrafast functional MRI, have enabled in vivo assessment of these mechanisms. Impaired glymphatic function has been linked to neurodegenerative and cerebrovascular diseases, highlighting its clinical relevance. Potential interventions range from lifestyle measures such as sleep optimization, exercise, and vascular risk control, to pharmacological and experimental strategies aiming to modulate CSF flow. These insights open new opportunities to target the glymphatic-lymphatic axis for the prevention and treatment of neurological disorders. |
| Key Words:
Glymphatic system | Neurodegenerative diseases | Cerebrospinal fluid |
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