레카네맙: 국내 알츠하이머병 치료의 현재와 미래

Lecanemab: Shaping the Present and Future of Alzheimer’s Disease Treatment in Korea

Article information

J Korean Neurol Assoc. 2025;43(3):194-195

Publication date (electronic) : August 1, 2025

doi : http://dx.doi.org/10.17340/jkna.2025.0026

Sung Hoon Kang, MD

Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea

강성훈

고려대학교 의과대학 고려대학교구로병원 신경과

Address for correspondence Sung Hoon Kang, MD Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea Tel: +82-2-2626-1250 Fax: +82-2-2626-1256 E-mail: shkang85@naver.com

received : June 20, 2025 , rev-recd : July 1, 2025 , accepted : July 1, 2025 .

[연관 대한신경과학회지 발표 문헌] DOI: https://doi.org/10.17340/jkna.2021.3.4

Professor Sung Hoon Kang

Audio. Lecanemab: shaping the present and future of Alzheimer’s disease treatment in Korea.

The Alzheimer’s disease treatment lecanemab has garnered significant attention as a groundbreaking therapy since its introduction in Korea in late 2024, due to its ability to intervene in the core amyloid pathology of the disease and slow its progression [1,2]. In this interview, we are joined by Professor Sung Hoon Kang, a dementia specialist at Korea University Guro Hospital, who has extensive clinical experience with lecanemab in real-world Alzheimer’s disease cases. We discuss the drug’s mechanism of action, indications, administration and monitoring strategies, as well as actual patient cases [3-5].

References

1. van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in early Alzheimer's disease. N Engl J Med 2023;388:9–21.

2. Chen C, Katayama S, Lee JH, Lee JY, Nakagawa M, Torii K, et al. Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease. J Prev Alzheimers Dis 2025;12:100160.

3. Park KH, Kim GH, Kim CH, Koh SH, Moon SY, Park YH, et al. Lecanemab: appropriate use recommendations by Korean Dementia Association. Dement Neurocogn Disord 2024;23:165–187.

4. Kang SH, Jeong JH, Pyun JM, Kim GH, Park YH, Shim Y, et al. Eligibility for lecanemab treatment in the Republic of Korea: real-world data from memory clinics. J Clin Neurol 2025;21:182–189.

5. Ashton NJ, Brum WS, Di Molfetta G, Benedet AL, Arslan B, Jonaitis E, et al. Diagnostic accuracy of a plasma phosphorylated Tau 217 immunoassay for Alzheimer disease pathology. JAMA Neurol 2024;81:255–263.

Article information Continued

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