A Patient with Anti-leucine-rich-glioma-inactivated 1 Encephalitis Initially Suspected as Wernicke-Korsakoff Syndrome

Yang, Seok-Yeol; Kim, Youngho; Seo, Jong-Geun

doi:2025.43.3.178

J Korean Neurol Assoc > Volume 43(3); 2025 > Article

Case Report

Journal of the Korean Neurological Association 2025;43(3): 178-180. doi: https://doi.org/10.17340/jkna.2025.0018

베르니케-코르사코프증후군으로 의심되었던 Anti-leucine-rich-glioma-inactivated 1 뇌염 환자

양석열¹, 김영호¹, 서종근^1,2

¹경북대학교병원 신경과
²경북대학교 의과대학 신경과학교실

A Patient with Anti-leucine-rich-glioma-inactivated 1 Encephalitis Initially Suspected as Wernicke-Korsakoff Syndrome

Seok-Yeol Yang MD¹, Youngho Kim MD¹, Jong-Geun Seo MD, PhD^1,2

¹Department of Neurology, Kyungpook National University Hospital, Daegu, Korea
²Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea

Corresponding Author: Jong-Geun Seo ,Tel: +82-53-200-5765, Fax: +82-53-422-4265, Email: jonggeun.seo@gmail.com

Received: May 11, 2025 Revised: June 11, 2025 Accepted: June 17, 2025 Published online: August 1, 2025

Abstract

Anti-leucine-rich-glioma-inactivated 1 (LGI1) encephalitis is the second most common type of autoimmune encephalitis, characterized by subacute disturbance of memory, behavior and other psychiatric disturbances. In the early stages of the disease, LGI1 encephalitis may clinically mimic other types of dementia or psychiatric disturbances, making early diagnosis challenging. Herein we report a case of LGI1 encephalitis that initially presented with clinical features resembling Wernicke-Korsakoff syndrome, underscoring the importance of including autoimmune encephalitis in the differential diagnosis of subacute neuropsychiatric syndromes.

Key Words: Korsakoff syndrome | Anti-LGI1 encephalitis | Autoimmune diseases of the nervous system