Oculopharyngeal Palsy in Patients with Coexistence of Anti-GQ1b and
GT1a Antibodies

J Korean Neurol Assoc > Volume 32(4); 2014 > Article

Journal of the Korean Neurological Association 2014;32(4): 275-278.

항GQ1b항체와 항GT1a항체가 동시 검출된 환자에서 공통적으로 나타난 안구인두마비

신재용, 박영은 a,b 신혜경 a 조기용 a 김종국 c 김대성

부산대학교 의학전문대학원 신경과 a , 부산대학교병원 의생명연구원 b , 동아대학교 의과대학 신경과 c

Oculopharyngeal Palsy in Patients with Coexistence of Anti-GQ1b and GT1a Antibodies

Jae-Yong Shin

Department of Neurology a , Pusan National University School of Medicine, Busan, Korea Biomedical Research Institute b , Pusan National University Hospital, Busan, Korea Department of Neurology c , College of Medicine, Dong-A University, Busan, Korea

Abstract

The presence of antiganglioside antibodies is closely associated with the clinical characteristics of Guillain-Barr? syndrome (GBS), as evidenced by the presence of anti-GQ1b antibody in Miller-Fisher syndrome and anti-GT1a antibody in a pharyngeal-cervical-brachial variant of GBS. We report herein three patients harboring both anti-GT1a and anti-GQ1b antibodies who all exhibited oculopharyngeal palsy and additional features of ataxia, facial palsy, internal ophthalmoplegia, and visual disturbance. The findings of this study suggest that oculopharyngeal palsy is a common clinical manifestation determined by the coexistence of anti-GQ1b and GT1a antibodies. Key Words: Guillain-Barr? syndrome, Anti-GQ1b antibody, Anti-GT1a antibody