Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid
Biomarkers for Alzheimer’s Disease

J Korean Neurol Assoc > Volume 32(2); 2014 > Article

Journal of the Korean Neurological Association 2014;32(2): 98-102.

알츠하이머병 뇌척수액 생물표지자 양성을 보인 로고페닉진행실어증

김형준, 김태은 김새로미 채원석 박선아

순천향대학교 의과대학 순천향대학교 부천병원 신경과, 마취과

Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease

Hyung-Jun Kim

Department of Neurology and Anesthesiology , Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea

Abstract

Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological, and radiologic data during 2?years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be similar to those found in Alzheimer’s disease, with a decreased concentration of Aβ42 and an increased concentration of pTau181 (tTau). Key Words: Biomarker, Cerebrospinal fluid, Logopenic aphasia