Paraneoplastic Necrotizing Myopathy Associated With Ovarian
Adenocarcinoma

J Korean Neurol Assoc > Volume 32(1); 2014 > Article

Journal of the Korean Neurological Association 2014;32(1): 34-37.

난소선암에 동반된 신생물딸림 괴사근병증

이혜미, 김지선 김민직 강성훈 홍진화 a 박성혜 b 김지현

고려대학교 의과대학 신경과학교실, 산부인과학교실, a 서울대학교 의과대학 병리학교실 b

Paraneoplastic Necrotizing Myopathy Associated With Ovarian Adenocarcinoma

Hye Mi Lee

Department of Neurology and Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea Department of Pathology, b Seoul National University College of Medicine, Seoul, Korea

Abstract

We describe here a case of female patient who presented with mild proximal weakness, myalgia, and markedly elevated CPK, which could be ascribed to paraneoplastic necrotizing myopathy in association with ovarian adenocarcinoma. A histologic examination of the vastus lateralis muscle showed necrosis of muscle fibers without inflammatory cell infiltration. Her neurologic symptoms improved following tumor resection and systemic chemotherapy. Paraneoplastic necrotizing myopathy may be a presenting manifestation of malignancy, and early recognition and prompt treatment are crucial for the clinical improvement. Key Words: Paraneoplastic myopathy, Necrotizing myopathy, Ovarian adenocarcinoma