2011 Update of Scientific Statement for the Primary Prevention of
Stroke: Dyslipidemia and Inflammation

J Korean Neurol Assoc > Volume 30(3); 2012 > Article

Journal of the Korean Neurological Association 2012;30(3): 159-169.

뇌졸중 일차예방을 위한 최신 과학적 근거(2011): 이상지질혈증과 염증

한상원, 김한영 a 박종무 b 구자성 c 조용진 d 강규식 b 유경호 e 나정호 f 허지회 g 권순억 h 오창완 i 배희준 j 이병철 e 윤병우 j 정진상 k 홍근식 d

인제대학교 의과대학 상계백병원 신경과, 건국대학교 의학전문대학원 신경과학교실 a , 을지대학교 의과대학 신경과학교실 b , 가톨 릭대학교 의과대학 신경과학교실 c , 인제대학교 의과대학 일산백병원 신경과 d , 한림대학교 의과대학 신경과학교실 e , 인하대학교 의과대학 신경과학교실 f , 연세대학교 의과대학 신경과학교실 g , 울산대학교 의과대학 신경과학교실 h , 서울대학교 의과대학 신경

2011 Update of Scientific Statement for the Primary Prevention of Stroke: Dyslipidemia and Inflammation

Sang Won Han

Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea Department of Neurology a , Konkuk University College of Medicine, Seoul, Korea Department of Neurology b , Eulji University College of Medicine, Seoul, Korea Department of Neurology c , Catholic University College of Medicine, Seoul, Korea Department of Neurology d , Ilsan Paik Hospital, Inje University College of Medicine, Ilsan, Korea Department of Neurology e , Hallym University College of Medicine, Anyang, Korea Department of Neurology f, Inha University College of Medicine, Incheon, Korea Department of Neurology g , Yonsei University College of Medicine, Seoul, Korea Department of Neurology h , University of Ulsan College of Medicine, Seoul, Korea Department of Neurosurgery i , Seoul National University College of Medicine, Seoul, Korea Department of Neurology j , Seoul National University College of Medicine, Seoul, Korea Department of Neurology k , Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

Background: This scientific statement is intended to provide a systematic review of new evidences in dyslipidemia and inflammation for primary stroke prevention.
Methods: Using a structured literature search, we identified major observational studies, clinical trials, meta-analyses, and updated major guidelines published between July 2007 and November 2010. In addition to the brief summary of earlier evidences employed in the first edition of Korean clinical practice guideline for primary prevention of stroke, we summarized the newly identified evidences.
Results: For dyslipidemia, observational studies further support a strong association between ischemic stroke and high total and low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol. Two clinical trials and meta-analyses confirm statin efficacy for primary prevention of stroke in high risk patients. Efficacy of other lipid-lowering agents is not established. For inflammation, inflammatory markers might help to identify patients having high risk for stroke or cardiovascular event and to decide whether statin therapy is indicated, but its usefulness for broad population needs to be confirmed.
Conclusions: Writing committee will continue to keep an eye on upcoming evidences to timely update the guideline primary stroke prevention in dyslipidemia and inflammation. Key Words: Dyslipidemia, Inflammation, Primary prevention, Scientific statement, Stroke