Serial Follow-up of White Matter Connectivity in a Patient with
Progressive Multifocal Leukoencephalopathy Presenting Clinical
Improvement

J Korean Neurol Assoc > Volume 29(4); 2011 > Article

Journal of the Korean Neurological Association 2011;29(4): 347-351.

임상적으로 호전된 진행다초점백질뇌병증 환자의 백질 내 해부학적 연결성 추적 관찰

정단일, 오성일 오경필 백원기 김희진 김승현

한양대학교 의과대학 신경과학교실

Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement

Dan-il Chung

Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea

Abstract

Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography. Key Words: Progressive multifocal leukoencephalopathy, Magnetic resonance spectroscopy, Tractography