Anti-NMDA Receptor Encephalitis

J Korean Neurol Assoc > Volume 29(4); 2011 > Article

Journal of the Korean Neurological Association 2011;29(4): 339-342.

Anti-NMDA 수용체 뇌염

강진휘, 이성현 신재원 안미영 백신혜 이형석 김지선 신동익 이상수

충북대학교 의과대학 신경과학교실

Anti-NMDA Receptor Encephalitis

Jin-Hwi Kang

Department of Neurology, College of Medicine, Chungbuk National University, Cheongju, Korea

Abstract

A severe, but reversible encephalitis associated with antibodies to the N-methyl-D-aspartate receptor (NMDAR) was identified recently in young women with ovarian teratoma. This condition has not been reported previously in Korea. A 31-year-old woman presented with fever and behavioral disturbances; she became comatose several days later, and dyskinesia and dysautonomia developed thereafter. Antibodies to the NMDAR were positive and abdominal computed tomography detected a large ovarian teratoma. The patient improved dramatically after the removal of the teratoma and administration of corticosteroid therapy. Key Words: Anti-NMDAR encephalitis, Teratoma, Dyskinesia