Intrathecal Chemotherapy Related Myelopathy Improved with Folate and Cyanocobalamin

J Korean Neurol Assoc > Volume 29(3); 2011 > Article

Journal of the Korean Neurological Association 2011;29(3): 224-226.

엽산과 시아노코발라민 투여로 회복된 경막내 화학요법과 연관된 척수병증

박수연, 박혜리 김지은 성정준

서울대학교 의과대학 신경과학교실

Intrathecal Chemotherapy Related Myelopathy Improved with Folate and Cyanocobalamin

Su-Yeon Park

Department of Neurology, Seoul National University College of Medicine, Seoul, Korea

Abstract

Intrathecal chemotherapy with methotrexate and cytarabine arabinoside is used for the treatment and prophylaxis of malignancies, but can induce myelopathy. We report the case of a 50-year-old woman with stomach cancer who developed myelopathy after administration of intrathecal cytarabine arabinoside and methotrexate. The patient’s neurologic status improved rapidly after the administration of folinate (15 mg) four times daily and cyanocobalamin (100 μg) once daily. The folate metabolites may be effective in the management of intrathecal-chemotherapy-induced myelopathy. KeyWords:Intrathecal chemotherapy, Myelopathy, Folate metabolites