Neuroleptic Malignant Syndrome Caused by Long Term Intake of Haloperidol

J Korean Neurol Assoc > Volume 29(3); 2011 > Article

Journal of the Korean Neurological Association 2011;29(3): 214-215.

장기간 할로페리돌을 복용한 환자에게 나타난 신경이완제악성증후군

조재훈, 박형종 박수신 하연수 이학승 박현영 장 혁 김요식 조광호

원광대학교 의과대학 신경과학교실, 원광의과학연구소

Neuroleptic Malignant Syndrome Caused by Long Term Intake of Haloperidol

Jae Hoon Jo

Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Korea

Abstract

Neuroleptic malignant syndrome (NMS) is a fatal complication most often caused by an adverse reaction to neuroleptic or antipsychotic drugs, and is mostly brought out in the initial stage of medication. Late onset NMS after long term intake of neuroleptics is uncommon, and the neurochemical mechanism is undiscovered. We report a patient of late onset NMS after a long term intake of haloperidol who was successfully treated with dantrolene and bromocriptine. KeyWords:Late onset neuroleptic malignant syndrome, Neuroleptics, Haloperidol