Characteristic Muscle Involvement on Magnetic Resonance Imaging in
Central Core Disease

J Korean Neurol Assoc > Volume 29(1); 2011 > Article

Journal of the Korean Neurological Association 2011;29(1): 31-33.

자기공명영상에서 특징적 근육 침범을 보이는 중심핵병

김지영, 김중구 이재영 강지훈 최재철 이정석 강사윤

제주대학교 의학전문대학원 신경과학교실

Characteristic Muscle Involvement on Magnetic Resonance Imaging in Central Core Disease

Jee Young Kim

Department of Neurology, Jeju National University School of Medicine, Jeju, Korea

Abstract

Central core disease (CCD) is a rare congenital myopathy characterized by central cores on muscle biopsy. We present three familial cases of CCD. The muscle pathology manifested as a predominance of type 1 muscle fibers and highly oxidative fibers with central cores. Muscle MRI showed selective involvement of the sartorius, vastus lateralis, and adductor magnus muscles. We suggest that muscle MRI can be used as an additional tool in the diagnosis of CCD. Key Words: Central core disease, MRI, Muscle