Bilateral Optic Neuritis as the First Manifestation of Systemic Lupus
Erythematosus Associated With Neuromyelitis Optica

J Korean Neurol Assoc > Volume 28(4); 2010 > Article

Journal of the Korean Neurological Association 2010;28(4): 323-325.

전신성홍반성루푸스의 첫 증상으로 양측 시신경염이 발생한 시신경척수염

노영, 강은하 a 황정민 b 김지수

서울대학교 의과대학 분당서울대학교병원 신경과, 내과 a , 안과 b

Bilateral Optic Neuritis as the First Manifestation of Systemic Lupus Erythematosus Associated With Neuromyelitis Optica

Young Noh

Departments of Neurology, Internal Medicine a , and Ophthalmology b , Seoul National University Bundang Hospital, Seongnam, Korea

Abstract

Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system that is characterized by severe episodes of transverse myelitis and optic neuritis. Aquaporin-4-specific autoantibody (NMO IgG) is the marker of NMO. We report herein a 28-year-old woman with systemic lupus erythematosus (SLE) that manifested with bilateral optic neuritis. She had NMO IgG in addition to clinical and serologic characteristics of SLE. This is the first report of a patient with SLE and NMO IgG that manifested with sequential bilateral optic neuritis. Key Words: Optic neuritis, Systemic lupus erythematosus, Neuromyelitis optica