| 토피라메이트를 복용한 간질환자의 삶의 질 평가 |
| 이정화, 손영민
a
서대원
b |
| 이화여자대학교 의과대학 신경과학교실 의과학연구소, 가톨릭대학교 의과대학 신경과학교실
a
,
성균관대학교 의과대학 삼성서울병원 뇌신경센터 신경과
b |
| Quality of Life Assessment in Epilepsy Patients With Topiramate |
| Jung Hwa Lee |
| Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, Korea
Department of Neurology
a
, The Catholic University of Korea, College of Medicine, Seoul, Korea
Department of Neurology
b
, Samsung Medical Center, Samsung Brain and Nerve Center, Sungkyunkwan University
School of Medicine, Seoul, Korea |
|
|
|
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| Abstract |
Background: Quality of life is important in epilepsy treatment. We evaluated the effect of topiramate on the quality of life
in epilepsy patients and on the characteristics of the clinical features in patients with improved scores on the Quality of
Life in Epilepsy Inventory?10 (QOLIE?10).
Methods: We included 631 adult epilepsy patients, who were followed for 16 ?weeks. We analyzed the effect of
topiramate on QOLIE?10 score. The patients were classified into those with improved scores (IG) and those whose scores
did not improve (NG). We compared each QOLIE?10 item and their clinical features between the IG and NG groups.
Results: All item scores, as well as the total score, improved after topiramate treatment. Comparison of the scores
for each item showed that working and social factor differences of both the IG (>0.72) and NG groups (>0.80)
were higher than for the other items. Age, gender, seizure onset, topiramate dose, adverse event, education level,
employment, and migraine did not differ significantly between the IG and NG groups. The effect on seizure
reduction was the most significant among the clinical features (P<0.001). The epilepsy syndrome, etiology, previous
antiepileptic drugs (AEDs), and weight changes did not differ significantly between the two groups (P<0.05).
Conclusions: Topiramate treatment can influence the quality of life in adult epilepsy patients, and especially work
and social factors. Seizure reduction, epilepsy syndrome, etiology, previous AEDs, and weight change may be the
most affected clinical factors in patients who have improved quality of life with topiramate. Key Words: Epilepsy, Seizure, Quality of life |
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